Three cases of Major Aphthous Stomatitis (Sutton’s Disease)

Treatment of severe, recalcitrant, major aphthous stomatitis with adalimumab.

We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha).

Recurrent Aphthous Stomatitis

Recurrent aphthous stomatitis (RAS) is a common disorder affecting 5% to 66% of examined adult patient groups. There may be a female predominance in some adult and child patient groups.1–4 The ulceration usually commences in the second decade,5 although 40% of selected groups of children can have a history of RAS, ulceration beginning before 5 years of age, the frequency of affected patients ri...

Recurrent aphthous stomatitis.

Remission of severe aphthous stomatitis of celiac disease with etanercept

Celiac disease is a common autoimmune disease triggered by gluten-containing foods (wheat, barley and rye) in genetically predisposed individuals. We present a patient with celiac disease complicated by severe aphthous stomatitis resulting in impairing swallowing, chewing and speaking. This led to weight loss, psychosocial problems as well as inability to perform her work. A variety of topical ...

Recurrent Aphthous Stomatitis: A Review

Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurring ulcers in the oral mucosa in patients with no other signs of disease. This condition is also called as Sutton’s disease, especially in the case of major, multiple or recurring ulcers. RAS appears to represent several pathological states with similar clinical manifestations, including immunologic disorders, hematologic ...